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  • 817bcda7dc Structure-binding track: scaffold + ligand-retrieval baseline structure-based-binding Junior B. 2026-06-23 23:53:27 +02:00
  • 6c2c71d73d PLAN §12.9: leave door open for generative-guided retrieval main Junior B. 2026-06-23 23:43:25 +02:00
  • 7449dbeefb Scope Phase 2 structure-based binding track into PLAN (§12) Junior B. 2026-06-23 23:40:18 +02:00
  • 649f617019 Phase D: supervised cross-disease (0.925 AUC degree-bias mirage) Junior B. 2026-06-23 23:31:32 +02:00
  • 0ce688449d Phase A: reference-library tau (negative result on specificity) Junior B. 2026-06-23 23:19:26 +02:00
  • b62048614d Experiment: composition-adjusted signature (negative result) Junior B. 2026-06-23 23:05:08 +02:00
  • 3417f85eb1 v1.1: full gene space + specificity z-score; hydroxyurea recovers Junior B. 2026-06-23 22:57:30 +02:00
  • 72f1a49de6 Week 4: recovery test (FAIL, reported honestly) + 2-page report Junior B. 2026-06-23 22:38:56 +02:00
  • fd4591949c Week 3: CMap connectivity scoring engine + ranked candidates Junior B. 2026-06-23 22:34:56 +02:00
  • 47b0094079 Week 2: 300-drug profiles with LINCS signatures + ChEMBL Junior B. 2026-06-23 22:25:00 +02:00
  • c7b6649d31 Week 1: Tier-A sickle cell signature via 2-study concordance Junior B. 2026-06-23 20:43:23 +02:00
  • b731478f5d Scaffold Reverso MVP pipeline structure Junior B. 2026-06-23 20:19:38 +02:00
  • e717cf40ed first commit Junior B. 2026-06-23 19:57:44 +02:00